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        • » A randomised controlled trial of alternative treatments to intramuscular penicillin for impetigo in Aboriginal children

A randomised controlled trial of alternative treatments to intramuscular penicillin for impetigo in Aboriginal children

 

Overview

This project, A randomised controlled trial of alternative treatments to intramuscular penicillin for impetigo in Aboriginal children, was developed by Menzies School of Health Research to determine if simple, cheap regimens of oral antibiotics will lead to equivalent cure rates of impetigo (skin sores) to those achieved with penicillin injections. The project also examined the relative contribution of Staphylococcus aureus to the development of impetigo.

The objectives of the project were to determine whether children, aged between 12 weeks to less than 13 years, who have been diagnosed with mild or severe impetigo have non-inferior cure rates at day seven when treated with oral trimethoprim-sulfamethoxazole compared to those treated with a single dose of intramuscular benzathine penicillin G (the current standard treatment).

508 children with impetigo (skin sores) were involved in the randomised controlled trial (RCT), based in the Northern Territory (NT).

The research found that short courses of oral antibiotics work just as well as the standard treatment with penicillin injections. This will be beneficial for children in remote communities needing treatment for their sores, as the oral antibiotic regimen is simple, short, tastes good and is pain-free.

Abstract adapted from Menzies School of Health Research

Contacts

Menzies School of Health Research
Project Manager
Irene O'Meara
John Mathews Building
Royal Darwin Hospital Campus
Rocklands Drive
Casuarina NT 0810
Ph: (08) 8922 8196
Fax: (08) 8927 5187
Email: Irene.Omeara@menzies.edu.au or operations@menzies.edu.au

Related publications

Bowen AC, Tong SYC, Andrews RM, O'Meara IM, McDonald MI, Chatfield MD, Currie BJ, Carapetis JR (2014)

Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial.

The Lancet; 384(9960): 2132–2140

Links

 
Last updated: 15 June 2016
 
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